Heineken

[Tapez le nom de la societe] 11 HEINEKEN [Tapez le sous-titre du document] poste Introduction I. The presentation of the company: HEINEKEN 1. A brief look at the history of Heineken 2. Brewing beer 3. Heineken product’s II. The presentation of market 1. Nature of marketing 2. Nature of applied research 3. Situation analysis of Heineken 4. Heineken and advertising III. My project 1. Product development strategy 2. Concept development and testing 3. Suggestions Conclusion Introduction: Heineken has wide international presence through a global network of distributors and breweries. Heineken owns and manages one of the world’s leading portfolios of beer brands and is one of the world’s leading brewers in term of sales volume and profitability. I. The presentation of the company: HEINEKEN 1. A brief look at the history of Heineken: The Heineken family entered the beer business in 1864, when Gerard Adrian Heineken bought a brewery in the heart of Amsterdam. Over the past 140 years, three generations of the Heineken family have built and expanded the brand and the company in Europe and around the world. It is thanks to the leadership of Gerard, Henry and Alfred Heineken that Heineken is one of the world’s leading brewing groups. The Heineken company name stands for many things. It began as a family business; three generations of Heineken, each with their own approach to building the business. It became Europe`s favorite beer brand – successfully exporting to every corner of the world. The history of Heineken starts on December 16th  1863. It was Gerard Adrian Heineken who, in 1864, bought the Amsterdam brewery â€Å"The Haystack†, which dated from 1592. In doing so, he laid the foundation for the Heineken concern, which was to acquire widespread international fame as time went by. Within a few years Gerard Adrian Heineken succeeded in increasing sales so much that the brewery in Amsterdam soon became too small. In 1867 construction of a new brewery began just outside the old city. His legacy was a brewery which had grown into one of the biggest and most important in the Netherlands. At the end of the nineteenth century, the competition from other breweries increased. From the 1950s onwards under the leadership of Alfred Heineken, who was the chairman of the Executive Board of Heineken NV, Heineken expanded to become an International Company. He gave the Heineken label worldwide fame and gave it a unique image. It was Alfred Heineken who came to the conclusion that beer was not a local or regional product but that beer could travel. He laid the basis for the international structure and organization of the Heineken concern. Thanks to the initiative of the Heineken family and its response to the changes in the world beer market, Heineken has grown to become the world`s most international beer brand. In the old days deliveries would be made by horse-drawn cart, but nowadays lorries take care of this. Loaded into the huge container ships in the port of Rotterdam, Heineken beer finds its way across the whole world. The export of Heineken beer took off at an early date. In the period between the two world wars, Heineken was exported to Belgium, France, Britain, West Africa and Indonesia. In 1933 Heineken became the first foreign brewery to export beer to the United States after the prohibition. That turned out to be a great success. But there is more – apart from exporting beer, Heineken also acquired stakes in the local breweries all over the world. It has also built its own breweries. Today, Heineken is sold in around 170 countries in all parts of the world; the company also has ties with 116 productions units in 57 countries. Heineken has in recent years been drawing attention to the Heineken brand by making increasing use of sponsorship. Heineken has recently sponsored the Rugby World Cup in South Africa, the  US Open, the  Davis Cup Tennis Tournament, the  Heineken Classic Golf Tournament  and the  Saint Maarten Regatta  in the Caribbean. Sports sponsorship is only one of the ways that Heineken can contribute to the lives of their customers. The Heineken brand is also strongly associated with music. They sponsor –  The Montreux,  Puerto Rico  and Umbria Jazz Festivals. 2. Brewing beer: Brewing beer is a 100% natural process. Heineken got its start when its founder fundamentally improved the process by which beer was made in a brewery that had existed for 251 years. The basic recipe is still closely guarded, and the principles of its success have remained the same: quality ingredients and a perfectly controlled brewing process. Heineken ingredients Heineken beer is made from the purest ingredients. It use only water, malted barley,  hops and yeast. Barley Barley is the major raw material used in brewing beer. Before it can be used for brewing, the barley grain must be malted. Malting helps make the starch and protein (by its natural enzymes) in barley available for brewing by breaking down the natural ce ll wall that surrounds the starch. Starch will be converted to sugar, which will produce alcohol during fermentation. Malting also forms the colour and flavour that the barley will lend to the beer. Hops Hops is one of the flavour-makers of beer, and also contributes to its shelf life. The resin from the female hop flower cones is used to help balance the sweetness of the barley with a refreshing bitterness. Water Beer contains almost 95% water. Water plays an important part in giving beer its characteristic flavor, as different sources contribute to unique beer flavors. Clean, high quality water is essential not only to our beer, but also to life everywhere. We are actively working in the communities that we're a part of to protect clean water supplies. Yeast Yeast converts malt sugars into alcohol during fermentation. There are two types: bottom and top fermenting yeast. Beers fermented with bottom yeast are called lagers and those that use top-fermenting yeast are called ales. In 1886 in Amsterdam, Dr. Elion, a student of Dr. Louis Pasteur, discovered the famous Heineken A-yeast, a strain that is still used today only by Heineken. Gluten Beer contains gluten, which comes from the grain from which it is brewed. Only a fraction of the gluten that the grain contains gets into the beer. The proportion depends on the kind of grain that is used. The use of barley results only in traces of gluten in the beer whilst wheat contributes considerably more. It also depends on the brewing process. Generally speaking: the clearer and blonder the beer is, the less gluten it may contain. Some people are allergic to gluten and have to follow a diet that minimises or excludes their gluten intake. Whether beer can be part of such a diet or not, is dependent on the extent of the allergy and the beer type consumed. In many cases lager beers pose no problem for people who have a gluten allergy. However, it is up to the individual to assess his or her sensitivity. * How beer is made Heineken beers are brewed using solely water, barley, hops and yeast. The barley is malted (soaked to initiate a natural geminating process), ground, mixed with water and then heated. Step by step, the temperature increases so that the starch in the malted barley is converted into sugars. After the solids have been filtered out, the result is ‘wort' (malt sugars), which is then brought to the boil. During the boiling process the brewers add the hops. Using only the female flowers of the hops plant gives beer its characteristic bitter taste and improves its storability. After the wort has been boiled, the next step is fermentation. First, the wort has to be cooled down to 8 degrees Celsius. Yeast is added to the wort and the process of converting the sugars into alcohol and carbon dioxide can then begin. This takes place in special fermentation tanks, where the beer remains for 7 days. The result is ‘young beer' which, when cooled down to freezing point, is pumped into storage cellars for post-fermentation. One of the aims of this storage is to improve the beer's taste and clarity, and help it keep longer. Once storage is completed, the remaining step is filtration, after which a superb-tasting, bright and clear beer is filled into bottles, can or kegs. Filling and bottling are automatic processes to ensure completely hygienic conditions. 3. Heineken product’s The icon: Wherever we go, it’s always nice to see something we recognize; the green bottle, the red star and the smiling â€Å"e†, telling us instantly what’s inside: cold, fresh, quality Heineken enjoyed around the world since 1873. Aluminum bottle Heineken  launches aluminum bottle  reserved  to  the nightlife  and  trendy  bars. Designed  by  design studio  Ora  Ito,  this is  a  refined  vision  of the  Heineken  bottle,  which  transforms it  into a true  collector’s item. Heineken  Draught Keg Real  beer  now  invites itself  at home  or  outside  with  the  new keg  pressure  to  carry, easy  to share in  any occasion. Heineken  has created  the first  disposable pressure  was offering  a  true  quality beer  pressure  as well  as  the  ability to consume  beer  until  30 days  after opening. Convenient  and friendly, combining  proprietary technology  with  a  unique  and patented  integrated  pressure,  a  refined design,  the  Heineken was  to win  an Oscar  for  the  package. Heineken  15cl  small Heineken  dares  the 2006  launch of  the  15cl  bottle. Revolution in the  beer  department,  small  and practical,  its  mini size  target consumes  occasional  beer. It  is  ideal  as an aperitif  for  those  wishing to  enjoy  a  Heineken while  controlling their consumption. In  the  world  of  night,  four  years  after  the  success  of  the aluminum bottle,  its  designer,  Ora Ito  renews  its  collaboration with  Heineken. With  smoother  lines,  a  refined  and conical shape,  the  new  aluminum bottle  made the bottle very elegant. II. The presentation of market 1. Nature of Marketing Marketing is the activity, set of institutions, and processes for creating, communicating, delivering, and exchanging offerings that have value for customers, clients, partners, and society at large. To efficiently accomplish their goals, ? rms today have adopted the marketing concept, which requires * A consumer orientation, * A goal orientation, * A systems orientation. A consumer orientation means that ? ms strive to identify the people (or ? rms) most likely to buy their product (the target market) and to produce a good or offer a service that will meet the needs of target customers most effectively in the face of competition. The second tenet of the marketing concept is goal orientation; that is, a firm must be consumer-oriented only to the extent that it also accomplishes corporate goals. The goa ls of profit-making firms usually center on financial criteria, such as a 15 percent return on investment. The third component of the marketing concept is a systems orientation. A system is an organized whole—or a group of diverse units that form an integrated whole— functioning or operating in unison. It is one thing for a ? rm to say it is consumer oriented and another actually to be consumer oriented. First, systems must be established to ? nd out what consumers want and to identify market opportunities. Identifying target market needs and ? nding market opportunities are the tasks of marketing research. Next, this information must be fed back to the ? rm. Without feedback from the marketplace, a ? rm is not truly consumer oriented. 2. Nature of Applied Research Marketing research studies can be classi? ed into three broad categories: programmatic, selective, and evaluative. Programmatic research is conducted to develop marketing options through market segmentation, market opportunity analysis, or consumer attitude and product usage studies. Selective research is used to test decision alternatives. Some examples are testing concepts for new products, advertising copy testing, and test marketing. Evaluative research is done to assess program performance; it includes tracking advertising recall, doing organizational image studies, and examining customer attitudes on a ? m’s quality of service. Programmatic research arises from management’s need to obtain a market overview periodically. For example, product management may be concerned that the existing market information base is inadequate or outdated for present decision making, or marketing plans may call for the introduction of new products, ad campaigns, or packaging. Typical programmatic research questions include the following: Has its target market changed? How? Does the market exhibit any new segmentation opportunities? Do some segments appear to be more likely candidates than others for the ? m’s marketing efforts? What new product or service opportunities lie in the various segments? 3. Situation Analysis of Heineken: Heineken is well-know, renowned brewery with essential strengths (Appendix-1) to be a global brand. However, at this moment, brand perception is different across the countries. Though Heineken had consistently been marketed as a premium brand, in the  US  and Hong Kong market, a distinct image was established for special occasion rather than for daily consumption while in  Latin America, Heineken is viewed as a European imported beer among others. The brand's good taste image is built on 5 core brand values: taste, premiumness, tradition, winning spirit and friendship. Heineken strategy is based on relating friendships and important relations which are built based on enjoyable, joyful, personal, luxury social conditions such as meeting people, fancy meals, savoring, elegant parties, intimate moments and place. The friendship value would be presented in several social conditions through â€Å"true friends† and â€Å"consumers can count on Heineken as a friend† expressions. The taste would be built on 5 brand values: taste experience, balanced taste, foam, advertising and packaging. Appendix-1: Strength and Weakness of Heineken Strengths| Weaknesses| * Beer of highest quality (superior quality) * Special Taste * Original formula * Traditions * Brands availability * Premium brand * Lighter Beer * Attractive packaging * Most heavily advertised Premium beer in  Europe  and Worldwide and use TV commercials  heavily| * No production base in some area * Inconsistent brand image with brand communication * TV commercials are just aired in larger markets * Lack f integrated marketing campaign * Lack of worldwide advertising campaign| Detailed recommendation to achieve the global brand * Introduce a number of innovations across liquid, packaging and format that will serve to further endorse international leadership credentials because innovation is the lifeblood of brand domain. * Heineken has a strong brand tradition. In order to flourish its  brand repu tation  across the world, convince the consumers that the brand is some way superior. Develop a relationship with customers, build  affinity  between brand and customers by sponsoring international rugby tournaments, and world soccer tournament such as -( the Champions Leagues, the UEFA Champions League,  world's premier club) where target audience of men from all over the world gather in one place. * Building the brand  recognition  for long-term  to differentiate the brand Heineken and be sure to add value to the product in order to get the brand loyalty. * Profile Heineken is one of the world's leading brewers in terms of sales volume and profitability and it has the widest presence of all international brewers through a global network of distributors and breweries. In volume terms, it has the largest brewer and beverage distributor in Europe, where it realizes more than half of its sales. It balances a strong position in stable and profitable markets such as Europe and North America with a growing presence in rapidly expanding beer markets such as China and Russia. It employs more than 60,000 people. The Heineken brand, available in almost every country on the planet, is the world's most valuable international premium beer brand. In addition, it owns and manages one of the world's leading portfolios of beer brands comprising other international premium, local and specialty brands. * Goal and market strategy Heineken's goal is to grow the business in a sustainable and consistent manner, while constantly improving profitability. The strategy to achieve this has four elements: †¢ Strive to reach a leading position in attractive markets. Focus on capturing an ever-growing share of the premium and specialty beer market segments. †¢ Work to improve efficiency and cut costs in operations. †¢ Grow through selective acquisitions, so long as they create shareholder value. * Brands Heineken owns and manages one of the world's leading portfolios of beer brands. Its principal international brands are Heineken and Amstel. Heineken is positioned as a premium brand, except for its home market in the Netherlands, and its appeal is growing in many markets. Heineken is the leading beer brand in Europe and Amstel is the third largest. In Europe, Amstel is positioned in the Mid-priced mainstream segment, the largest segment of the market, and is available in more than 90 countries around the world. Heineken also owns and manages a strong portfolio of more than 120 top-selling brands that includes Cruzcampo, Z. ywiec, Birra Moretti, Murphy's and Star. It has a limited presence in the low-priced segment of the market and its international and local brands include lagers, specialty beers, light beers (low-calorie beers) and alcohol-free beers. * Distribution Heineken is the largest beer and beverage distributor in Western Europe. In every market where it is active, it strives for comprehensive coverage through alliances with independent distributors or via its own beverage wholesalers. * Innovation Heineken works to continually meet consumers' changing needs. This can be seen in the area of marketing communication, packaging and dispense systems, where it is a recognized leader. It also works to further improve the quality, safety and cost structure of processes and products. This includes innovation in brewing technology and supply chain management, which reinforces the competitiveness of its global brand portfolio. Sustainability Heineken is committed to conducting business responsibly and ethically. It continuously takes its initiatives to combat alcohol abuse, misuse and focused resources and energy on setting even higher standards in the social and environmental areas of its business. 4. HEINEKEN and advertising: Heineken beer is a famous brand name in around the world and Ads plays the important role in the dissemination of Heineken. At the beginning, Heineken has appeared on mass media with advertisements and promotion programs very attractive, unique; use the words easy to understand. Heineken is not only a beer; Heineken is the moment comes with the image and inspiration to everyone, anytime, and anywhere. The Heineken Ads actually attracts viewers to the world of Heineken – a strange world – World of the passion. Therefore, when mention to Heineken, people immediately think about a new lifestyle has been confirmed with the events has made the impressive, such as: Heineken & Music, Heineken & Sports and Heineken & Movies. Besides Sport and Music, Heineken also sponsored to release the series of action films of Hollywood. Indeed, there were many companies chose movie is the part of the marketing plan. So what is the difference in the way of Heineken? The biggest difference is the investment, has demonstrated a long-term strategy. Starting in 2005 with the movie â€Å"Mr. & Ms. Smith†, Heineken wanted to announce that Heineken will provide viewers the excellent films. Nextly, in the summer of 2008, audiences once again be watched â€Å"Wanted† with the high technique screen and very impressive, never seen in any movie at Hollywood. in 2006, Heineken sponsored to release: † Casino Royal â€Å". Heineken, bring the passion of peak quality, the investment to the distribution system and the media attractive, has confirmed the top brand name of beer in the world. Heineken is respectfully support all of customers, who always discover and enjoy the best of life III. My project: 1. Product Development strategy Given the rapid changes in consumer tastes technology arid competition companies must develop a steady stream of new products and services. When an organization introduces a product into a market they must ask themselves some questions. . Who is interested by this kind of product? 2. What profits will they expect? 3. How to introduce the product in the market? 4. What differential advantage will the product offer over their competitors? The product should be viewed in three levels: Level 1: Core Product. What is the core benefit of your product offers? Customers who purchase a camera are buying more : they are purchasing memories. Level 2 : Actual Product: All the camera cap tures memories. The aim is to ensure that your potential customers purchases for you one. The strategy at this level involves organizations branding, adding features and benefits to ensure that their product offers a differential advantage from their competitors. Level 3: Augmented product: What additional non-tangible benefits can you offer? Competition at this level is based around after sales service, guaranties, delivery and so on. John Lewis a retail departmental store offers for free five years of guarantee on purchases of their Television sets, this gives their `customers the additional benefit of peace of mind over the five years. As they will be quiet if their purchase develop a technical problem. . Concept development and testing An attractive idea must be developed into a product concept. It is important to distinguish between a product idea, a product concept, and a product image. A product idea is an idea for a possible product that the company can see itself offering to the market. A product concept is a detailed version of the idea stated in meaningful cons umer terms. A product image is the way consumers perceive an actual or potential product. Who is the target market and who is the decision maker in the purchasing process? What product features must the product incorporate? What benefits will the product provide? How will the consumers react to the product? What will it cost to produce it? 3. Suggestions: In  today's consumer society, competition  is  increasingly  fierce. Consumers  are less  loyal  to brands  than before. Therefore  they must  remain  in  continuous innovation  in order  to  avoid  routine  and weariness  of the consumer. For  these  reasons,  the  brands are trying  to  find  new  ideas  to maintain  their  sales  and maintain  their visibility  and  attraction. 1st idea: The  creation  of  a  packaging  event  is a solution  that  strengthens the brand’s image  and  market positioning. This  type  of  packaging, launched  in  small quantities,  can  maintain  a sense  of  scarcity  of  the product. Indeed, creating a limited edition is an opportunity to do something different and to test consumer loyalty to the brand and transform it to a collector which will increase the turnover of the company. Besides, a unique and limited packaging may give the company a luxurious image because it reflects his constant search for innovation and thus seduced 2nd idea: I think that is a great idea to cover the cans by a protective film, in order o keep them hygienic and protect them against all forms of pollution. This protects  consumers  from  germs  that  can  accumulate over  the can especially that they are  in direct contact  with the  mouth. 3rd idea: Here are some facts about women and beer: * The sale of beer to women is a growing market. * Women currently account for 25 percent of beer consumption in the USA. * Women between t he ages of 21 and 30 are drinking more beer than women in other age groups. * Beer drinking among women in the 50-plus age group is on the increase, a fact that has not gone unnoticed among beer advertisers worldwide. Women beer drinkers are a discerning bunch. They demand more of their beer: more flavor, more complexity, more fruitiness, fewer calories and lower carbs. Above all, women want beer with more style and character. So, I propose to this target: women who enjoy beer; a light beer with lower alcohol content. This beer will package into new bottle with an exceptional shape which attract feminist target. 4th idea: Conversely to the can of NESCAFE I suggest a new system: It is a refrigerated can which cools when it is opening. This ensures the beer’s conservation and quality. The concept of this product is to permit the end user to consume fresh beer of very high quality. It can be consume all the time and never having to access a kitchen, refrigerator or even having to rely on an external cooling source. * All  these  ideas  will  be  developed  in a  second  report. It  will  explain why the  choice  of each  idea,  and the techniques  of achievement Conclusion: Marketing strategy allows us to generate a specific response from targeted groups of customers. It can help us to achieve the following key objectives: * increasing sales to existing customers * building customer loyalty re-establishing lapsed customer relationships * generating new business At  a broader level marketing offers significant benefits to society. These benefits include: * Developing products that satisfy needs, including products that enhance society’s quality of life * Creating a competitive environment that helps lower product prices * Devel oping product distribution systems that offer access to products to a large number of customers and many geographic regions * Offering techniques that have the ability to convey messages that change societal behavior in a positive way.

Ethical Self-Assessment

Healthcare professionals are faced with making multi-faceted decisions on a daily basis. These decisions are not just limited to clinical matters, but they include the total patient care experience. Because of emerging healthcare trends and complex health law and ethics, it is imperative that healthcare administrators have a professional organization that they can belong to. â€Å"The American College of Healthcare Executives (ACHE) is an international professional society of more than 35,000 healthcare executives who lead hospitals, healthcare systems and other healthcare organizations.ACHE is known for its prestigious FACHE ® credential, signifying board certification in healthcare management, and its educational programs including the annual Congress on Healthcare Leadership† (American College of Healthcare Executives, n. d. ). The Ethics Self–Assessment Tool and Individual Decision Making The American College of Healthcare Executives (ACHE) provides an ethics self -assessment which is made up of thought-provoking questions to serve as a moral compass using the ACHE Code of Ethics as its basis.No matter what your role in the healthcare system, the self-assessment provides a standard for various healthcare relationships including, â€Å"Community, Board, Colleagues, Staff, Clinicians, Buyers, Payors and Suppliers. † (American College of Healthcare Executives, n. d. ). Any questions that were not answered with â€Å"always,† identified an area of weakness in which ethics were being compromised. The first lesson learned is that there are numerous situations where healthcare professionals may believe they are being ethical, but the assessment provides examples that some decisions being made are unethical.This gap away from being completely ethical occurs because professional decisions are often influenced by individual ethics. Identifying these gaps allow healthcare administrators to make necessary steps to improve the method in whic h they make decisions. Another lesson learned is the importance of having a tool to compare your organization’s level of ethics to the code of ethics. Paying special attention to minimize outside influences, will allow you to make complex ethical decisions at all times which will promote consistency throughout all team members and the organization.The American College of Healthcare Executives (ACHE), has a strong impact on ethical decision making because they focus on the â€Å"entire being† of the healthcare professional. For example, in ACHE’s preamble of The Code of Ethics it states, â€Å"In fulfilling their commitments and obligations to patients or others served, healthcare executives function as moral advocates and models. † Imagine, when a healthcare administrator recites these few words, he cannot help but acknowledge the depth of his commitment and the high level of morality that is expected from him.Because of the vast number of complex ethical dilemmas that arise, ACHE further promotes the value and importance of strong ethical decision making in ACHE’s Ethics Toolkit. â€Å"When the ethical guidelines are not enough, when there is uncertainty about the proper ethical approach, and when there is a need to develop additional ethical guidelines. ACHE’s Ethics Toolkit provides tools for developing both parts of an ethical culture. † (American College of Healthcare Executives, n. d. ).Influence of Individual Ethics on Decision Making. When it comes to the modern decisions in today’s healthcare system, it is important to be able to identify problems and opportunities and choose the best course of action for the greater good. A strong ethical background helps individuals make the right decision although it may be unpopular. â€Å"Aristotle (Summers, 2009) also teaches about morality when explains how to apply ethics to daily living. Through the idea of practical wisdom and eudemonia, he makes us aw are of the need to apply ethics and behave in a moral way.We develop our moral character so that we use our knowledge of ethics to address challenging new situations. Ethical principles become the center of our lives and we apply them as virtue-centered administrators. † Strategies to Improve Decision Making in the Future The opportunities that being a member of The American College of Healthcare Executives (ACHE) has afforded healthcare professionals, is one that is here to stay. Healthcare administration is a profession that continually evolves with time. Because of the advances in medicine, people are living longer and have a better quality of life.The current self-assessment tools are quickly improving and making it easier for healthcare professionals to obtain the data needed to make prompt ethical decisions. It is important to remember that as a healthcare professional, one must present all of the facts to a patient and preserve his right of autonomy. It is within the co de of ethics that healthcare professionals are not to impose their will on someone else. Remember, to carry out â€Å"the four ethical principles of autonomy, beneficence, nonmaleficence, and justice. †

Analysis Chaos in Jurassic Park Essay Example for Free

Analysis Chaos in Jurassic Park Essay Jurassic Park: Absurd Chaos The main story of Jurassic Park written by Michael Crichton is about genetically cloned dinosaurs who break loose. Confusion and complete disorder occurs throughout the story of Jurassic Park. In the story, the theme of chaos is unpredictably built in the human’s lives. Dr. Ian Malcolm predicts that having dinosaurs in Isa Nubla will cause disaster. If the animals are released to the island, they will be a liability because they will disrespect nature. Malcolm is the most famous mathematician who predicts chaos countless of times in the park. The reeding of dinosaurs are the main cause that create chaos and destructs Jurassic Park. Malcolm foresees that the creation of dinosaurs is not a smart idea, for it can cause unpredicted behavior. Malcolm is a scientist who is outgoing, egoistic and has the knowledge to create new ideas. Malcolm states that it is ‘†an attempt to recreate a natural environment from the past† (Crichton 92). Dinosaurs are known to be as an ancient species that only existed long ago. Having the idea creating dinosaurs in Jurassic Park is bizarre to humans. Nature is the biggest problem Jurassic Park has at becoming successful. Having the idea of using the dinosaurs as the park entertainment on an island is Just sounds like a major trap under no circumstance. Malcolm’s calculation has gradually built up the story more precise. As stated by Dr. Malcolm in the book, he said â€Å"Life will find a way†(139). He meant that the dinosaurs will find a way to live the way they want. This is something that scientists didn’t think about when they brought dinosaurs back to life. The scientists didn’t think about the way that nature would want to live and decided that they could control it. Dr. Malcolm uses the chaos theory to predict the collapse of the park. In the beginning of the book Malcolm is introduced to the story. One of the first things Dr. Malcolm talks about is the chaos theory. In the first conversation with him in the book Malcolm said, â€Å"Theory tells me that the island will quickly proceed to behave in unpredictable fashion†(76). What Malcolm means by this is that without even visiting the park he can say that it will fail. Dr. Malcolm is a problem in the story because convinces other people that Jurassic Park is a bad idea. Dinosaurs represent unnatural habitats to the current society. However Hammond, a billionaire developer, decides to breed dinosaurs in the park. Dr. Hammond’s main conceptual idea is to earn a lot of money from the rich tourists so he can build more Jurassic Parks in other countries. He is self centered, greedy and stubborn who is unaware that dinosaurs can ultimately cause destruction. Crichton writes, miou know what’s wrong with scientific power? It’s a form of inherited wealth. And you know what assholes congenitally rich people are† (122). This shows that Hammond’s objective is to gain wealth and not for the sake of saving the environment. He is blind to the fact that recreating dinosaurs will only bring negativity to the current world. Creating more dinosaurs will undoubtedly ring chaos to the park. The cloning of dinosaurs starts from John Hammond. Hammond hired scientists and doctors to make his creation come true. In particular, a scientist named Dr. Wu, a young graduate and whom Hammond hires is beginning work. Dr. Wu’s objective is to control the number is reproduce dinosaurs in the park. By doing so, he thought that putting genetically mortified frog DNA into the missing DNA in dinosaurs will stop dinosaurs reproduction, but in reality, doing this enables the dinosaur’s DNA to switch genders and have the ability to reproduce. Furthermore, Crichton writes, â€Å"All major changes are like death. You can’t see to the other side until you are there. † (167). After he changed the DNA, the dinosaurs kept reproducing and Dr. Wu and his team had no control over the number of reproduced dinosaurs. Malcolm mentions, â€Å"All major changes are like death. You can’t see to the other side until you are there. â€Å"(175). This is where chaos and unnatural catastrophe begins in Jurassic Park. Before the grand opening of the Jurassic Park, Malcolm anticipates that having unnatural species is a tragic demise to Jurassic Park, known as the â€Å"Malcolm Effect†. The â€Å"Malcolm Effect† theory is when the â€Å"island will quickly roceed to behave in unpredictable fashion†¦ There is a problem with that island. It is an accident waiting to happen. ‘† (84). Overtime Malcolm’s prediction begins appear later on in the story. The author writes, â€Å"Living systems are never in equilibrium. They are inherently unstable. They may seem stable, but theyre not. Everything is moving and changing. In a sense, everything is on the edge of collapse â€Å"(164). Drastic changes occur when the dinosaurs begin to reproduce and when Malcolm and Hammond engage in an argument. Hammond is relieved that the animals did not get free and overrun the world. Malcolm says that the world cannot be demolished by human’s creation. Due to the major problem of dinosaurs breeding, dinosaurs are eager to break loose from the Jurassic Park and begin to overpopulate the island In Malcolm’s calculation it says, â€Å"Life breaks free. Life expands to new territories†(160). Malcolm thinks Jurassic Park has ‘inherent instability’ or that it is impossible to control even when the analysis is carried out using computer models. The story considers dinosaurs as the most interesting creatures that anyone has ever witnessed. For example, t-rexs, tyrannasaurs, velocipators and triceratops are the ypes of dinosaurs that are chaotic because they use techniques to kill their prey. The way they use the skills to kill the humans were unique because velociraptor works as a communicative group. Many Raptors may have hunted in packs, often ranging in large numberings. They have a primitive level of vocalization, which enables them to direct attacks and call for help. They are also able to set traps. All the dinosaurs have a right skill sets that can cause chaos. Stubborn scientist, dinosaurs breeding cause chaos. Problems add up and there is not anything that will stop it. Dr. Malcom, Dennis Nedry and the way of nature all caused things to go wrong. There is not any way to control nature. As Ian Malcolm incorporated chaos theory into his calculations, all of these events were predicted in one way or another. The count of animals was much higher than expected due to reproducing. Animals are able to escape due to the fences when being powered off by Denis Nedry. Systems began to fail and caused substantial problems throughout the book. Ian Malcolm had it right, â€Å"Chaos theory proves that unpredictability is built into our daily lives. â€Å"(313). There is not any way to control nature. No one can stop chaos once it begins. Analysis Chaos in Jurassic Park. (2018, Nov 05).

Driessen Essay Example | Topics and Well Written Essays - 750 words

Driessen - Essay Example Paul Driessen's book Eco-Imperialism: Green Power, Black Death considers the subject of how the extremists of the environmental lobby within the rich and developed countries of the west are pushing their own ecological standards upon those of the less developed world (Driessen, 2003). Paul Driessen has worked within the Senate and Department of the Interior as well as being involved in support groups. However, through out his time in Washington he has slowly realised that the process of support for the environment has slowly ground to a halt, or has become so blinkered by its own ideologies that it has stopped accepting fresh new ideas and evidence that would help saves the lives of billions (Driessen, 2003). Driessen puts forward the statement that has been argued by many that the environment and theories concerning its values should always be taken into consideration and placed over saving human lives. This statement and its actions is seen as being the cause of so many lives being lost in the third world countries (Driessen, 2003). What makes matters worse is that many of these eco-imperialist groups are advocating the need to heal the earth, these groups include Greenpeace, who through the many years of its existence may have used up more oil on it's boat the rainbow warrior than any other shipping or whaling industry. Their aim and agenda is to save the world but at the cost of human life, which sadly can be found in much of the third world (Driessen, 2003). Driessen illustrates that those eco-imperialists are purposely and deliberately forcing their own ideals onto the world and as such are responsible for the death of so many lives around the globe. It is ideas such as the removal of DDT as a pesticide that has caused the rise of mosquitoes. This has caused the death of nearly 2 million people a year in sub Saharan Africa (Driessen, 2003). Driessen points out that when DDT is sprayed in the homes there is no risk to the environment or to people. Moreover, it has been illustrated that by using DDT the South African government had stemmed the number of deaths to around 10,000 per year. Sadly when DDT was halted the deaths rose to a staggeringly 62,000 a year and again fell when DDT was reintroduced (Driessen, 2003) Furthermore, the book illustrates the change in economies and demands for new doctrines for Corporate Social Responsibility, in this the demands are placed upon these groups instead of their own goals and profits, sadly once these ideals are defined then the policies that look at human suffering and misery become less important in favour of profit (Driessen, 2003). Driessen offers up the new ethical codes as a questionable way for the eco-imperialists to push for their ideologies upon the world (Driessen, 2003). The argument by such groups that invoke the eco-imperialistic ethos that science, technology and industry should be removed or refused to the third world countries can be seen as once again elitist, how can a country develop if it is refused the technology in which to do so. Many of the third world countries population seek to move out of their stone age huts and live in modern houses with electricity and clean fresh running water, the kind of things at many in the west take for granted. Yet these poor people are denied even the right of living like modern humans by elitist groups whose only ideal is their own back yard

Transparency in the cost of justice Statistics Project - 1

Transparency in the cost of justice - Statistics Project Example One of the major impediments with EU legal system is the hefty fee for lawyers and the reason for this is four-fold. Secondly, significant differences in sources and levels of costs from one member state to the other also constitute a barrier. Thirdly, the high costs in relation to the quantity of litigations frequently act as an obstacle. Fourthly, significant differences among the member states legal systems entail enhanced costs to initiate cases as the litigant has to pay for translators and lawyers apart from bearing the expenditure on travel and notifications. This study contains an analysis of data on four types of costs for four case studies based on the data acquired from 28 European countries. Cost data has been taken under four heads, such as court costs, lawyer costs, bailiff costs and appeal costs. Court cases of four types have been considered and the costs are calculated for all cases. The categories of cases include CA1A: National situation, in which a couple gets mar ried and subsequently they separate and agree for a divorce, CA1B: Transnational situation. That is two nationals from a similar member state get married and afterward file for a divorce, CA4A: National situation, which includes commercial and contract law and CA4B: Comprising transnational situation in Commercial Law and Contract. The above graph represents CA1A: National situation where a couple gets married. Later they separate and agree to a divorce in different European countries. It can be seen that the lawyer cost in the instant case is common in all countries. Italy has a high lawyer cost in CA1A. Ireland, Poland, Luxembourg, Estonia, Austria, UK are comparatively cheaper in lawyer fee. Lawyers, as legal experts deal with legal costs that have a bearing on the restoration of the privileges of litigants to carry out the litigation costs. The costs are better in UK probably because of transparent court procedures. Lawyers’ fees form the most significant part of the

Visuals and page design Essay Example | Topics and Well Written Essays - 500 words

Visuals and page design - Essay Example e of the measures that can be put in place include revoking or suspending drivers’ licenses for persons found of such offenses, confiscating number plates of such drivers, and increasing penalties for the crimes. On the other hand, the pedestrians must not use phone while crossing roads. Moreover, drivers must evade the use of phones at all times especially while driving or alighting from their vehicle since the same my interfere with their personal judgment while driving and distract them thereby placing other road users including themselves in gravies dangers. Road users must protect each other at all costs by ensuring they do not create, increase, and do any risky behavior while using the roads. Notably, the government and society have for many years cooperated in improving safety on our roads; therefore, for those who are unable to use the road safely must consider hiring or requesting for designated drivers. Statistics has it that most fatal accidents are caused by persons driving under the influence of alcohol among other drugs or persons with high content of alcohol in their blood (BAC). It is vital that all road users to have their 100 percent concentration on the road; hence, the use of phones while using the roads must be evaded at all costs. Opposed to the road accidents caused by mobile phone users, drunk drivers are known to cause most of the accidents. However, with strict traffic laws and sensitization, accidents caused through drunk driving have reduced drastically since 1982 from a height of 60 percent of total road accidents to 39 percent in 2005. Shockingly, the trend changed in 2005 in an increasing trend to 42 percent in 2010. This has been attributed for by the increased use of phone especially accounted for by the social media that seems to be taking the world crazy (Martinez 142). Changes in the percentage shows how better the society and the authorities have worked towards improving road fatalities; however, reinforcement of all other

Visible Organizational Culture Essay Example | Topics and Well Written Essays - 500 words

Visible Organizational Culture - Essay Example organizational units, enhancing cross-cultural management, developing teamwork support and sustaining workforce diversity management successfully (Baker, 2002). McDonald’s Corporation is recognized to be one of the foremost foodservice retailers in the world which possesses over 33,000 local restaurants that serve approximately 68 million individuals in a single day in 119 countries. The organization has focused upon various areas that include delivering quality products to its customers, ensuring sustainable management of supply chain and maintaining their environmental responsibility in order to make constant improvements in the upcoming years (McDonald’s, 2012). A visible organizational culture often involves the policies, values, procedure manuals and organizational charts of an organization. In this similar context, the imperative business values of McDonald’s include depicting dedication to offer incomparable levels of cultural values to its employees, offering better quality service as well as cleanliness to its large base of customers and most importantly performing its business operations with integrity and honesty. The other noteworthy business values of McDonald’s include its commitment to the working personnel of the company by delivering various attractive opportunities in terms of rewards, ethically conducting business operations, growing the business more profitably and striving continuously to enhance in order to attain more profitability in the long term (McDonald’s, 2012). From the perspective of the organizational culture, it has been viewed that McDonald’s holds a sturdy organizational culture. Due to its strong organizational culture, the organization has enjoyed overwhelming success in comparison with other competitors in the world. One of the imperative facets of McDonald’s is that it is well known worldwide for the deliverance of standard menus to its valued customers with outstanding product quality. Moreover, the

Dosing of cephalosporines in renal failure pateints Research Proposal

Dosing of cephalosporines in renal failure pateints - Research Proposal Example Aim- To understand the dosing of Cephalosporin in Renal failure patients. Method and Design Physical examination- should be performed for edema, ascites, dehydration. Measurement of body weight and height is performed. In obese patients the ideal body weight should be calculated and dose of drug should be planned consequently. Renal function- Estimation of creatine clearance (the volume of blood plasma that is cleared of creatinine in a unit time). Elimination of drugs is directly proportional to GFR (drugs excreted by kidneys). The Cockroft- Gault equation to estimate Clcr for age between 40- 80 years. Clcr (mL/min) = (140-age)x weight in kgs / 72 x serum creatinine (in mg/ dL) x (0.85 for women). Assessment of GFR from serum creatinine level presumes the stability of renal function and also formulate that serum creatinine measurement is constant. If there is alteration in renal function, the creatinine level does not indicate the true clearance. In case of oliguria, Clcr is approxi mated as 10mL/min. In cases with acute renal failure, the non-renal clearance of medicines diminishes by means of time window of renal failure. In the initial course of the therapy, personalized pharmacokinetic dose for patients with severe renal impairment is vital.

Effective schools are inclusive schools Essay Example | Topics and Well Written Essays - 2500 words

Effective schools are inclusive schools - Essay Example Normally, a disabled child is sent into a school specifically designed for them or their parents may opt to hire a private tutor that will facilitate the child's education. This is not the case for inclusion. In theory, inclusion states that all student are part of a so-called school society and that students regardless of their physical or mental limitations are entitled to the same level of education that a normal child experiences and that disabled children must develop a sense of belonging with other children, his or her teachers and other school personnel regardless of his or her condition. The concept of inclusion was much well accepted that it gave rise to IDEA in 1997. IDEA is actually an acronym that stands for Individuals with Disabilities Education Act, and it states that schools should provide the necessary tools and techniques necessary to facilitate the learning process of children with disabilities given a normal classroom environment ("Inclusion, 2006; Department of S pecial Education, 2006). Thus far, inclusion has been well received and is also said to be quite effective even for those suffering from autism. However, inclusion has been proven to have high maintenance costs, though these costs can be justified by its effectivity as some experts claim. But in any case, inclusion provides what every child (whether normal or disabled) needs in a proper learning environment: a sense of belongingness as well as a group of friends that are willing to accept him or her despite his or her disabilities. Furthermore, inclusion provides disabled children a number of benefits that were previously unavailable to them such as housing and healthcare (Harchick, 2005). The Definition of Inclusion Inclusion is a teaching method in which children with physical or mental disabilities are integrated in a normal classroom occupied by normal students. It is intentionally constructed to fill in the needs of disabled students ("Inclusion", 2006). Foreign languages for example, are taught using a variety of activities facilitated by educators and specialists which guide both normal and disabled students through the whole learning process. A typical class in an inclusive school appears to be a normal classroom except that there are times that the class may be a little noisier than usual but this is all part of promoting creativity, resourcefulness and productivity among students (Department of Special Education, 2006). Some experts divide into two more categories: partial and full inclusion. Technically, partial inclusion states that a disabled child needs only to be in the classroom for about two-thirds of the total number of school days. In full inclusion, the disabled child is required to attend all of his or her schooldays in the classroom ("Inclusion", 2006) An inclusive school also discourages competition among its students and it is though of to be student centred. Students are also encouraged to set up their own rules and policies and in turn everyone is expected to abide by it, in effect an inclusive school teaches a student how to become a functional and beneficial part of society (Department of Special Education, 2006). Recent Studies about Inclusion The core concept behind inclusion that students who have been

EMMA LARKINS FINDING GEORGE ORWELL IN BURMA Essay

EMMA LARKINS FINDING GEORGE ORWELL IN BURMA - Essay Example The army heightened a state of lawlessness that denied and extorted the people’s little resources to fulfil their political responsibility and unsustainable democracy in their society. The military government of Burma has showed similarities with the British colonial government in many ways for example it led to split of allegiances among different ethnic groups and also between the indigenous people of Burma (Larkin, 2011).  Also ethnic minorities were not allowed to acceses land, it also resulted to religious conflicts between the muslims, budhist, hindus and Christians in Burma. Their was aslo displacement of citizen both inside and outside Burma. Besides forced labour by the military has also been expirieced which has led to the human rights violation as well as explotaiton of the minority goups. Some of the tools used by post colonial government of Burma was one the tgroup identity where the minority were given the priority to manage local properties and istitutions. secondly rebellion rebellion was employed where the minority were rqruited into the police army surpressing the majority Burman. Thirdly the nationalist tool was used where the Burmese language and ethnicity was emphasized because of the cultural and religious diversity of Burman. The fear to loose power as suggested by Aug snag suu kyi led to all injustices of human right violation, ethnicity,forced labour and so on in Burman. Leaving Burma alone fear has been employed in many countries for example employees who advocate for their rights are threatened to be arrested hence they fear and step down.

Any form of captivity Essay Example for Free

Any form of captivity Essay Animals should not be kept in any form of captivity. Animals belong in their natural habitat. It is a breach of their natural rights to take them away, and put them behind bars. All animals that are kept in captivity should be realized into the wild. Healthy News In zoos around the world animals are suffering Weird News. Every day animals are taken out of their natural habitat and put behind bars, purely for our beneï ¬ t. Studies have shown that these animals are suffering form severe cases of depression, abnormal behavior and physiological distress. How does the bird feel in the cage when he can clearly see his wild cousin ï ¬â€šying free from his conï ¬ ne many people visit zoos so they are able to gain greater knowledge of how animals behave and operate. These people want to see the animals acting naturally, how they would in the wild. The only way to understand an animal properly is to see it in its natural environment. Zoos give totally artiï ¬ cial and misleading views by isolating animals from there ecosystem. If people want to see how animals behave they should go out into the wild to see real animals, not ones who are physiologically distressed? More questions. In some poorer zoos the conditions are extremely bad. Most of them keep their animals in wire cages which are often too small to allow the animals to move around. Most of these cages have cement ï ¬â€šoors and lack any opportunities for the animals to act naturally. To make it worse most of these animals die young due to the harsh conditions they are forced to live with. Many zoos are absolutely disgraceful Zoos are cruel jails for these animals and should be outlawed unless they provide the animals with a friendly and roomy habitat, good food and good medical care. Most unfortunately do not †¦ I cannot imagine what life must be like for these animals in your gallery and thousands like them the world over †¦and Zoos are indeed a double-edged sword. Some people claim that zoos help protect endangered animals. Some owners even think that cage is a good discipline for a pet which will calm the and make them pay attentionbut for some it causes depression and more fear from the animal more that loyalty. In my opinion I am fully against cages for animals that can cause either mental or physical pain. The only reason I would consider it an option is if you had multiple dogs and one needed it’s own privacy if it has been returned from the vets or it has been suffering from stress of other pets in the home. There is no medical need for an animal to be kept inside a cage from it’s beneï ¬ cial point of view because it has no advantages from the fact that it can only separate the pet from the outside world. No animal deserves to be treated like a prisonerit has some emotional effects on the pet which can become permanent and it could change the pet for good.

Commercial company Essay Example for Free

Commercial company Essay Select a major industrial or commercial company based in the United States and listed on one of the major stock exchanges in the United States. Each student should select a different company. Avoid selecting an insurance company or a bank, because the financial ratios for these financial businesses are different. Write a seven-to-eight-page double-spaced paper answering and demonstrating with calculations and financial data the following questions. 1. What is the name of the company? What is the industry sector? Starbucks Corporation is in the Food and Beverage industry 2. What are the operating risks of the company? Economic conditions in the US and certain international markets could adversely affect Starbucks’ business and financial results. – as a retailer Starbucks is dependent upon the customer’s discretionary spending. Customers may have less money for discretionary purchases as a result of job losses, foreclosures, bankruptcies, increased fuel and energy costs, higher interest rates and taxes. Decreases in customer traffic will negatively impact financial performance. Starbucks may not be successful in implementing important strategic initiatives or effectively managing growth, which may have an adverse impact on our business and financial results. – there is no assurance that Starbucks will be able to implement strategic initiatives and achieve the results that are within management’s expectations. These initiatives are designed to create growth, improve operations and drive long-term shareholder value. Starbucks face intense competition in each of our channels and markets, which could lead to reduced profitability. Starbucks is highly dependent on the financial performance of the America’s operating segment – the Americas operating segment contributes 74% of the total net revenues in fiscal 2013. Starbucks is relying on the success in the European/ Middle East, China/Asia Pacific operating segments to achieve overall growth targets. Other international operations are also subject to additional inherent risk when conducting business abroad. Of which, include: Forex rate fluctuations. Changes or uncertainties in economic, legal, regulatory, social and political conditions in international markets. Restrictive actions of foreign or US governments affecting trade. Enforceability of intellectual and contract rights. Local laws Disruption in energy supplies. Delays in store opening beyond the control of management. Increases in the cost of high-quality Arabica coffee beans or other commodities. Disruption in the supply chain, which will impact the ability to deliver Starbucks’ products. The loss if key personnel or difficulties in recruiting and retaining qualified personnel Adverse public or medical opinions about the health effects of consuming Starbucks’s products, as well as reports of incidents involving food-borne illnesses, food tampering or food contamination. Starbucks relies heavily on information technology in operations, and any material failure, inadequacy, interruption or security failure of that technology could harm Starbucks’ ability to effectively operate the business. Failure to comply with local laws and regulations. 3. What is the financial risk of the company (the debt to total capitalization ratio)? Market Cap: 56.69 BN Debt: 2.05BN Debt/total cap ratio = 0.036 (yahoo.com, 2014) 4. Does the company have any preferred stock? The company does not have preferred stock. 5. What is the capital structure of the company: short-term portion of long-term debt, long-term debt, preferred stock (if any), and market value of common stock issued and outstanding? short-term portion of long-term debt 357.7 Million Long-term debt 1,299 Million Preferred Stock 0 Market value of common stock 56.69 Billion 6. What is the company’s current actual beta? 0.95 7. What would the beta of this company be if it had no long-term debt in its capital structure? Unlevered Beta using Hamada equation = Beta /[1+(1-T) x (D/E)] Beta : 0.95 Marginal Tax Rate, T: 32.8% D/E: 0.036 Unlevered Beta = 0.96 / [1+(1 -0.328)*0.036] =0.937 8. What is the company’s current marginal tax rate? Income taxes for the fiscal year ended 2012 resulted in an effective tax rate of 32.8% compared to 31.1% for fiscal year 2011. (Starbucks Coffee Company, 2013) 9. What is the price earnings multiple of the company? Price to earnings ration. This ratio is used in conjunction with other metrics to give analyst and investors are quick initial impression of whether a company would make a good investment. (investopedia, 2014) Starbucks P/E ratio is 385.05 10. How has the company’s stock been performing in the last 5 years? Starbucks share price 282.32% in the last 5 yrs. 11. Would you invest in this company? Why or why not? I would invest in Starbucks. SBUX has the highest P/E ratio among its competitors. Their cost of debt is low compared to their cost of equity. That is why they are relying on debt for their expansion. Their dividends per share have been increasing yearly. 18. The last page of your paper should be a Bibliography of the sources you used to prepare this paper. Bibliography investopedia. (2011, feb). Cost of Equity. (investopedia) Retrieved septmeber 2014, from Investopedia: www.investopedia.com/terms/c/costofeqquity.asp investopedia. (2014). Definition of Prince Multiple. Retrieved from www.investopedia.com: www.investopedia.com/terms/p/princemultiles.asp Starbucks Coffee Company. (2013). Fiscal 2013 Annual Report. Investor Relations. Seattle: Starbucks Coffee Company. yahoo.com. (2014, september). Yahoo Finance. (Yahoo.com, Producer) Retrieved september 2014, from Yahoo finance: finance.yahoo.com/q/ks?s=SBUX+Key+Statistics

N Acetylcysteine Quality Control

N Acetylcysteine Quality Control N-acetylcysteine (C5H9NO3S Mr 163.2) is the N-acetyl derivative of the naturally occurring amino acid, l-cysteine. The drug occurs as a white, crystalline powder with a slight acetic odor. N-acetylcysteine is freely soluble in water and in alcohol. N-acetylcysteine is commercially available as aqueous solutions of the sodium salt of the drug. It is used as a mucolytic or as an antidote for paracetamol. The British Pharmacopoeia contains a number of tests for this compound designed to ensure the quality. N-acetylcysteine acts to reduce mucus viscosity by splitting disulfide bonds linking proteins present in the mucus (mucoproteins). Inhaled N-acetylcysteine is indicated for mucolytic (mucus-dissolving) therapy as an adjuvant in respiratory conditions with excessive and/or thick mucus production. Such conditions include emphysema, bronchitis, tuberculosis, bronchiectasis, amyloidosis, pneumonia. It is also used post-operatively, as a diagnostic aid, and in tracheostomy care. It may be considered ineffective in cystic fibrosis (Rossi, 2006). However, a recent paper in the Proceedings of the National Academy of Sciences reports that high-dose oral N-acetylcysteine modulates inflammation in cystic fibrosis and has the potential to counter the intertwined redox and inflammatory imbalances in CF (Tirouvanziam et al., 2006). Oral N-acetylcysteine may also be used as a mucolytic in less serious cases. N-acetylcysteine also acts to augment glutathione reserves (depleted by toxic paracetamol metabolites) in the body and, together with glutathione to directly bind to toxic metabolites. These actions serve to protect hepatocytes in the liver from toxicity due to paracetamol overdose. Intravenous N-acetylcysteine is indicated for the treatment of paracetamol (acetaminophen) overdose. Oral N-acetylcysteine for this indication is uncommon as it is poorly tolerated owing to the high doses required (due to poor oral bioavailability), unpleasant taste or odour and adverse drug reactions (particularly nausea and vomiting). However, some people have shown an adverse allergy to intravenous N-acetylcysteine which includes extreme breathing difficulty, light-headedness, rashes, severe coughing and sometimes also vomiting. Repeated overdoses will cause the allergic reaction to get worse and worse. N-acetylcysteine is prone to both hydrolysis and oxidation and some of the impurities from these reactions are shown below. Scheme 2 2. Experimental: 2.1. Materials: The materials used in this experiment were N-acetylcysteine powder, disodium edentate solution, 1M sodium hydroxide and mixed phosphate buffer pH 7.0, water, dilute hydrochloric acid, potassium iodine solution, 0.05M iodine, 0.1M sodium hydroxide, starch, phenol red and phenolphthalein as indicators. The apparatus used were optical rotation analyser, conical flasks, 10mL and 50mL pipettes, burette, electronic weigh balance and beakers. 2.2. Methods: a) Specific optical rotation: +21ÃÅ'Ã…   to +27ÃÅ'Ã…   1.25g N-acetylcysteine powder was weighed and allowed dissolve in a mixture of 1ml of 10g/L solution of disodium edentate, 7.5ml of 1M sodium hydroxide and sufficient amount of mixed phosphate buffer pH 7.0 to 25ml total volume. Optical rotations of the freshly prepared solution and the old solutions of N-acetylcysteine provided were measured and recorded. b) ASSAY: 98.0%-101.0% C5H9NO3S (as dried material) 0.14g N-acetylcysteine powder was weighed by difference and poured into a conical flask. 60 ml of water and 10ml dilute hydrochloride acid were measured and added into the conical flask. The conical flask was shaking to ensure the N-acetylcysteine powder was fully dissolved. The solution was left to cool. Another 10ml of potassium iodide solution was added into the cooled solution in the conical flask. The solution was then titrated with 0.05M iodine by using starch as indicator. Second titration was carried out to ensure accurate and precise result. c) Assay by titration with 0.1M sodium hydroxide 0.3g N-acetylcysteine powder was weighed by difference and poured into a clean conical flask. Approximately 50 ml of distilled water was measured and added into the conical flask. The conical flask was shaking to ensure the N-acetylcysteine powder was fully dissolved. The solution was titrated with 0.1M sodium hydroxide using phenol red as indicator. Second titration was carried out to ensure accurate and precise result. 0.3g N-acetylcysteine powder was weighed by difference and poured into a clean conical flask. Approximately 50 ml of distilled water was measured and added into the conical flask. The conical flask was shaking to ensure the N-acetylcysteine powder was fully dissolved. The solution was titrated with 0.1M sodium hydroxide using phenolphthalein as indicator. Second titration was carried out to ensure accurate and precise result. d) Zinc: Not more than 10ppm Zinc 1.00g of N-acetylcysteine powder was weighed and dissolved in 0.001M hydrochloric acid. The solution was diluted to 50ml with 0.001M hydrochloric acid and solution 1 was obtained. Three solutions were prepared for analysis. The first solution consists of 10ml solution 1 diluted to 20ml with 0.001M hydrochloric acid, second solution consists of 10ml solution 1 and 1ml of 5ppm zinc standard diluted to 20ml with 0.001M hydrochloric acid and the third solution consists of 10ml solution 1 and 2ml of 5ppm zinc standard diluted to 20ml with 0.001M hydrochloric acid. The absorbance of each solution was measured at 213.8nm using an atomic absorption spectrophotometer. The absorbance for each solution was tabulated. The zinc content in each sample was calculated using the method of standard addition. e) Loss on drying: Not more than 1.0%w/w A sample of N-acetylcysteine was dried at 70ÃÅ'Ã…   C in vacuo for 3 hours and the data was recorded and the percentage loss on drying of this sample was calculated. f) Related substances The chromatograms obtained from the HPLC analysis of both fresh solution and old solution of N-acetylcysteine was examined. 3. Results: a) Specific optical rotation: Mass of weighing boat(g) 26.6089 Mass of weighing boat + sample (g) 27.8609 Mass of weighing boat + residue (g) 26.6079 Mass of sample transferred (g) 1.253 Table 1: The mass of N-acetylcysteine used to make a solution for measurement of specific optical rotation. Calculations: According to British Pharmacopoeia (BP 1999; page 40-41), it states that the specific optical rotation is +  21.0 to +  27.0. To obtain the angle of rotation, the equation below is used, Where, [ÃŽÂ ±] = specific optical rotation ÃŽÂ ± = observed angle of rotation C = concentration of active substance in g/100mL of the solution l = length of column in 2dcms For freshly prepared solution: Angle obtained (ÃŽÂ ±): 2.45à ¢Ã‚ Ã‚ ° Concentration of N-acetylcysteine (c): 5.012 %w/v Path length = 2 dm Specific optical rotation: = 100 x 2.45à ¢Ã‚ Ã‚ ° 2 x 5.012g/ml = +24.5à ¢Ã‚ Ã‚ ° For old solution: Angle obtained (ÃŽÂ ±): -3.29à ¢Ã‚ Ã‚ ° Concentration of N-acetylcysteine (c): 5.012 %w/v Path length = 2 dm Specific optical rotation: = 100 x 3.29à ¢Ã‚ Ã‚ ° 2 x 5.012g/ml = -32.9à ¢Ã‚ Ã‚ ° b) ASSAY: 98.0%-101.0% C5H9NO3S (as dried material) Sample 1 Sample 2 Mass of boat + sample (g) 3.8797 3.8777 Mass of boat + residue (g) 3.7393 3.7398 Mass of Acetylcysteine transferred (g) 0.1404 0.1379 Table 2: The mass of N-acetylcysteine powder in sample 1 and sample 2 for titrations with iodine. First reading Second reading Initial volume (mL) 17.40 26.70 Final volume (mL) 26.40 35.50 Volume of 0.05M iodine used (mL) 9.00 8.80 Table 3: The volume of iodine used for both titration using sample 1 and sample 2 of N-acetylcysteine solution and starch as indicator. Calculations: Actual concentration of iodine used: 0.0476M Molecular weight of N-acetylcysteine (C5H9NO3S): 163.2 The balanced equation for the reaction between N-acetylcysteine and iodine: 2 C5H9NO3S + I2 à   C5H8NO3SSC5H8NO3 + 2HI 2KI à   I2 + 2K+ According to British Pharmacopoeia, 1mL of 0.05M iodine is equivalent to 16.32mg of C5H9NO3S. This means, 2 mole of C5H9NO3S equal to one mole of iodine. Therefore when 1mL of 0.05M iodine = 16.32mg of C5H9NO3S, 1mL of 0.0476M iodine = 0.0476M x 16.32mg/ 0.05M = 15.54mg of C5H9NO3S First titration: 1mL of 0.0476M iodine = 15.54mg of C5H9NO3S So, 9.00mL of 0.0476M iodine = 9.00mL x 15.54mg/ 1mL = 139.86mg = 0.13986g of C5H9NO3S Second titration: 1mL of 0.0476M iodine = 15.54mg of C5H9NO3S So, 8.80mL of 0.0476M iodine = 8.80mL x 15.54mg/ 1mL = 135.52mg = 0.13552g of C5H9NO3S Calculation of Percentage of Purity: Sample 1 of N-acetylcysteine Sample 2 of N-acetylcysteine Mass transferred Actual mass calculated Mass transferred Actual mass calculated 0.1404 0.1399 0.1379 0.1355 According to British Pharmacopoeia (BP), the percentage of purity should be within 98.0 101.0% of dried substance. Equation of the Percentage of Purity: Sample 1: Sample 2: c) Assay by titration with 0.1M of sodium hydroxide i) Titration by using phenol red indicator Sample 1 Sample 2 Mass of boat + sample (g) 3.8916 3.9199 Mass of boat + residue (g) 3.5913 3.6198 Mass of N-acetylcysteine transferred (g) 0.3003 0.3001 Table 4: The mass of N-acetylcysteine powder in sample 1 and sample 2 for titrations with 0.1M of sodium hydroxide. First reading Second reading Initial volume (mL) 1.00 1.00 Final volume (mL) 18.15 18.10 Volume of 0.05M iodine used (mL) 17.15 17.10 Table 5: The volume of 0.1M sodium hydroxide used for both titration using sample 1 and sample 2 of N-acetylcysteine solution and phenol red as indicator. Calculations: Actual concentration of sodium hydroxide (NaOH) used: 0.1062M Molecular weight of N-acetylcysteine (C5H9NO3S): 163.2 The balanced equation for the reaction between N-acetylcysteine and sodium hydroxide (NaOH): C5H9NO3S + NaOH à   C5H8NO3SNa + H2O From the equation, one mole of N-acetylcysteine reacts with one mole of NaOH. So the reaction is a 1:1 ratio. To find out the number of mole of NaOH, the equation below is used: First titration: Moles of NaOH = (0.1062M x 17.15mL)/1000 = 1.821 x10-3 moles As the reaction is 1:1 ratio so the number of moles of N-acetylcysteine is equal to the number of moles of NaOH used which is 1.821 x10-3 mole. Mass of N-acetylcysteine = 1.821 x10-3 moles x 163.2 = 0.2972g Second titration: Moles of NaOH = (0.1062M x 17.10mL)/1000 = 1.816 x10-3 moles As the reaction is 1:1 ratio so the number of moles of N-acetylcysteine is equal to the number of moles of NaOH used which is 1.821 x10-3 mole. Mass of Acetylcysteine = 1.816 x10-3 mole x 163.2 = 0.2964g Calculation of Percentage of Purity: Sample 1 of N-acetylcysteine Sample 2 of N-acetylcysteine Mass transferred Actual mass calculated Mass transferred Actual mass calculated 0.3003 0.2972 0.3001 0.2964 According to British Pharmacopoeia (BP), the percentage of purity should be within 98.0 101.0% of dried substance. Equation of the Percentage of Purity: Sample 1: Sample 2: ii) Titration by using Phenolphthalein as the indicator Sample 1 Sample 2 Mass of boat + sample (g) 3.8916 3.9195 Mass of boat + residue (g) 3.5915 3.6195 Mass of N-acetylcysteine transferred (g) 0.3001 0.3000 Table 6: The mass of N-acetylcysteine powder in sample 1 and sample 2 for titrations with 0.1M of sodium hydroxide. First reading Second reading Initial volume (mL) 18.20 17.10 Final volume (mL) 36.80 36.95 Volume of 0.05M iodine used (mL) 18.60 19.85 Table 7: The volume of 0.1M sodium hydroxide used for both titration using sample 1 and sample 2 of N-acetylcysteine solution and phenolphthalein as indicator. Calculations: Actual concentration of sodium hydroxide (NaOH) used: 0.1062M Molecular weight of N-acetylcysteine (C5H9NO3S): 163.2 The balanced equation for the reaction between N-acetylcysteine and sodium hydroxide (NaOH): C5H9NO3S + NaOH à   C5H8NO3SNa + H2O From the equation, one mole of a N-acetylcysteine reacts with one mole of NaOH. So the reaction is a 1:1 ratio. To find out the number of mole of NaOH, the equation below is used: First titration: Moles of NaOH = (0.1062M x 18.60mL)/1000 = 1.975 x10-3 mole As the reaction is 1:1 ratio so the number of moles of N-acetylcysteine is equal to the number of moles of NaOH used which is 1.821 x10-3 mole. Mass of N-acetylcysteine = 1.975 x10-3 mole x 163.2 = 0.3224g Second titration: Moles of NaOH = (0.1062M x 19.85mL)/1000 = 2.108 x10-3 mole As the reaction is 1:1 ratio so the number of moles of N-acetylcysteine is equal to the number of moles of NaOH used which is 1.821 x10-3 mole. Mass of N-acetylcysteine = 1.816 x10-3 mole x 163.2 = 0.3440g Calculation of Percentage of Purity: Sample 1 of N-acetylcysteine Sample 2 of N-acetylcysteine Mass transferred Actual mass calculated Mass transferred Actual mass calculated 0.3001 0.3224 0.3000 0.3440 Calculation of Percentage of Purity: According to British Pharmacopoeia (BP), the percentage of purity should be within 98.0 101.0% of dried substance. Equation of the Percentage of Purity: Sample 1: Sample 2: d) Zinc: Not more than 10ppm Zinc (Zn): To determine the concentration of Zinc metal present in a standardised sample, atomic absorption spectrophotometer was applied. This was done so as to comply with the British Pharmacopoeia (BP) standards, where the detected concentration of Zinc should not be more than 10ppm. Mass of Acetylcysteine sample used: 1.00g This sample was diluted accordingly and then analysed or measured by an atomic absorption spectrophotometer at a set wavelength of 213.8nm. According to the laboratory transcript, the absorbances were given, so the calculation was carried out to determine the concentrations for each solution. Solution Concentration (mg/L) Absorbance (at 213.8nm) (a) 0.00 0.056 (b) 0.25 0.115 (c) 0.50 0.173 Table 8: The absorbance of solution a, b and c using atomic absorbance spectrophotometer. From the table 8 above, a standard additions calibration graph of concentration of zinc in mg/L against absorbance at 213.8nm is plotted. A rather small absorbance indicates that there is a trace or small amount of Zinc (Zn) present in Solution A, which practically contained only the N-acetylcysteine sample. Hence, we can plot a line of best fit and extrapolate to find the concentration of Zn present within our sample. Note that the amount of Zn present is proportional to the absorbance detected at 213.8nm wavelength. Graph 1: The graph of absorbance against concentration of Zinc. Extrapolated value= -0.24 Solution A = 0.24ppm Solution 1 = 0.24 ÃÆ'- 2 = 0.48 ppm Solution 1 0.48g in 100 000 mL = 2.4 ÃÆ'- 10-4g in 50 mL If 1g of N-acetylcysteine contains 2.4 ÃÆ'- 10-4g of zinc ions, 104g of acetylcysteine will contain 2.4g of zinc ions. So concentration of zinc ions in N-acetylcysteine = 2.4ppm Using the calibration graph, we obtained an equation for the line of best fit as shown below: Using the line of best fit we can calculate the concentration of Zinc (Zn) present within Solution 1. This is determined by the difference between the origin (x = 0) and where the line of best fit intercepts the x-axis. To be more accurate, the equation of the line of best fit can be used by assuming the absorbance of N-acetylcysteine at 213.8nm (y-axis) is 0 (y = 0). We can then calculate and find the exact concentration of Zn added (x-axis in mg/L) which gives an absorbance reading of 0.0562 at the wavelength of 213.8 nm. This calculation is shown below where absorbance y = 0. Concentration of Zinc in solution (a) where no Zinc is added:- (Concentration comes in positive value) Therefore, the diluted Solution 1 contains an exact concentration of 0.2402mgL-1 or 0.2402ppm. We can now use this concentration and work backwards from the dilution to obtain the mass of Zn within the 20mL Solution 1, as shown in the calculation below, Mass of Zinc in Solution 1:- From the mass of Zinc present in Solution 1 as calculated, we can say that this equals to the 10mL of N-acetylcysteine sample in Solution (a). This is because Solution 1 was diluted to 20mL using 0.001M hydrochloric acid and contained no other sources of Zinc. Hence, 4.8034ÃŽÂ ¼g of Zinc in 20mL of Solution 1 is equal to 4.8034ÃŽÂ ¼g of Zinc in 10mL of Solution (a). Now using this mass of 4.8034ÃŽÂ ¼g in 10mL of Solution (a) we can find out the total mass of Zinc within 50mL. However, the total mass of Zinc within 50mL of Solution (a) is equivalent to 1.00g of N-acetylcysteine sample which is the original sample mix. Using these data, the mass of Zinc can be calculated as shown in the calculation below, Mass of Zinc in 1.00g of N-acetylcysteine: Hence, 2.4017ÃŽÂ ¼gmL-1 of Zinc is present in 1.00g. We can now calculate an exact concentration of Zinc in parts per million (ppm) as shown in the calculation below, Concentration of Zinc within sample in ppm:- e) Loss on drying: Not more than 1.0% w/w:- Initial mass of N-acetylcysteine sample (g) 1.0965 Mass after drying under specified conditions (g) 1.0893 f) Related substances 1) Acetylcysteine: fresh sample 8.57mg/mL From British Pharmacopoeia, the retention time for the N-acetylcysteine substances as below. Substance Retention time (min) L- cystine About 2.2 L- cysteine About 2.4 2-methyl-2 thiazoline-4 carboxylic acid About 3.3 N,N-diacetyl-L- cystine About 12 N,N-diacetyl-L- cysteine About 14 acetylcysteine About 6.4 1) Acetylcysteine: fresh sample 8.57mg/mL Substance Retention time (min) Peak retention time obtained Concentration L- cystine About 2.2 1.93 0.5948 L- cysteine About 2.4 2-methyl-2 thiazoline-4 carboxylic acid About 3.3 3.25 0.0794 N,N-diacetyl-L- cystine About 12 N,N-diacetyl-L- cysteine About 14 13.623 0.3944 Acetylcysteine About 6.4 6.972 94.7507 Calculation of impurities: Peak area/ Total area x 100 Substance Area Concentration Impurity L- cystine 238606 0.5948 0.5948 L- cysteine 2-methyl-2 thiazoline-4 carboxylic acid 31861 0.0794 0.0794 N,N-diacetyl-L- cystine N,N-diacetyl-L- cysteine 158211 0.3944 0.3944 Acetylcysteine 38007440 94.7507 94.7507 Total area= 40113072 2) Acetylcysteine: old sample 2.5mg/mL Substance Retention time (min) Peak retention time obtained Concentration L- cystine About 2.2 2.11 0.7214 L- cysteine About 2.4 2-methyl-2 thiazoline-4 carboxylic acid About 3.3 3.256 0.8946 N,N-diacetyl-L- cystine About 12 N,N-diacetyl-L- cysteine About 14 13.415 15.3284 Acetylcysteine About 6.4 6.34 33.7241 Calculation of impurities: Peak area/ Total area x 100 Substance Area Concentration Impurity L- cystine 62935 0.7214 0.7214 L- cysteine 2-methyl-2 thiazoline-4 carboxylic acid 78046 0.8946 0.8946 N,N-diacetyl-L- cystine N,N-diacetyl-L- cysteine 1337263 15.3284 15.3284 Acetylcysteine 2942118 33.7241 33.7241 Total area= 8724087 3) Cysteine/ cystine: 0.5mg/mL Substance Retention time (min) Peak retention time obtained Concentration L- cystine About 2.2 2.018 5.2956 L- cysteine About 2.4 2.323; 2.65 2.3189; 2.384 2-methyl-2 thiazoline-4 carboxylic acid About 3.3 3.008; 3.207 24.9029; 65.0987 N,N-diacetyl-L- cystine About 12 N,N-diacetyl-L- cysteine About 14 Acetylcysteine About 6.4 Calculation of impurities: Peak area/ Total area x 100 Substance Area Concentration Impurity L- cystine 87001 5.2956 5.2956 L- cysteine 38097; 39167 2.3189; 2.384 2.3189; 2.384 2-methyl-2 thiazoline-4 carboxylic acid 409128; 1069503 24.9029; 65.0987 24.9029; 65.0987 N,N-diacetyl-L- cystine N,N-diacetyl-L- cysteine Acetylcysteine Total area= 1642895 4. Discussion: a) Specific optical rotation: The specific rotation of a chemical compound [ÃŽÂ ±] is defined as the observed angle of optical rotation ÃŽÂ ± in stereochemistry, when plane-polarized light is passed through a sample with a path length of 1 decimetre (dm) and a sample concentration of 1 gram (g) per 1 millilitre (mL). The specific rotation of a pure material is an intrinsic property of that material at a given wavelength and temperature. The reading should be accompanied by the temperature at which the measurement was performed and the solvent in which the material was dissolved, and this often assumed to be room temperature. The exact unit for specific rotation values is deg dmà ¢Ã‹â€ Ã¢â‚¬â„¢1cm3 gà ¢Ã‹â€ Ã¢â‚¬â„¢1 or can use degrees (ÃÅ'Ã…  ). Levorotatory rotation (l) means a negative reading obtained and the rotation being to be left. While dextrorotatory rotation (d) means a positive reading and the rotation is being to be right. The specific optical rotation for the freshly prepared solution of N-a cetylcysteine is +24.5à ¢Ã‚ Ã‚ ° which it is dextrorotatory rotation and the old solution of N-acetylcysteine is -32.9à ¢Ã‚ Ã‚ ° which means levorotatory rotation. Measurement of optical rotation is a way to assess optical purity of a sample containing a mixture of enantiomers. An enantiomer is one of two stereoisomers that are mirror images of each other that are non-superposable or not identical much as ones left and right hands are the same but opposite. The specific optical rotation of N-acetylcysteine solution is within the range +21ÃÅ'Ã…   to approximately +27ÃÅ'Ã…  . The freshly prepared of N-acetylcysteine solution is found to be in the range however the old N-acetylcysteine solution is not in the range. This reveals stability alteration occurred in the old N-acetylcysteine solution. The impurities have found in the old N-acetylcysteine solution because the presence of small amount of impurities can affect the rotation of the sample. The actual optical rotation value for freshly prepared N-acetylcysteine solution is measured by single polarimeter because if the sample is very concentrated or it has very large specific rotation or the sample larger than 180 °, single polarimeter cannot be used. The variation of specific rotation with wavelength is the basis of optical rotary dispersion (ORD) which used to elucidate the absolute configuration of certain samples. High performance liquid chromatography (HPLC) is used to determined the enantiomeric ratio with a chiral column because the aggregation in the N-acetylcysteine solution cause optical rotation of a sample maybe not linear dependent due to enantiomeric excess. b) ASSAY: 98.0%-101.0% C5H9NO3S (as dried material) From the result obtained above, the mass obtained from the titration of N-acetylcysteine solution with iodine with starch as indicator for first titration is 0.13986g and second titration is 0.13552g. The percentage of purity obtained from the experiment for first sample is 99.64%. The percentage of purity from second sample is 98.26%. According to British Pharmacopoeia (BP), the percentage of should be within 98.0 101.0% of dried substance. The percentage of purity for both samples is within the range stated in the BP. BP prefer the iodine titration to a titration using sodium hydroxide because iodine is a very useful oxidising titrant which react with reducing agent ,N-acetylcysteine solution using starch as indicator. Iodine forms an intensely dark blue complex with starch. Starch is an oxidation reduction indicator that shows a reversible colour change between the oxidised and reduced forms. It is not affected by the presence of iodide (I-). Both starch and iodide must be prese nt for the starch to change colour during the titration. Iodine is consumed by thiosulfate in the titration step. The amount of thiosulfate used is proportional to the amount of iodine liberated from the salt. Sodium hydroxide is a strong base. It is more useful in acid- base titration using weak acid or base indicator. c) Assay by titration with 0.1M of sodium hydroxide From the result obtained in this experiment, the mass obtained from the titration of N-acetylcysteine solution with0.1M sodium hydroxide with phenol red as indicator for first titration is 0.2972g and second titration is 0.2964g. The percentage of purity obtained from the experiment for first sample is 98.97%. The percentage of purity from second sample is 98.77%. According to British Pharmacopoeia (BP), the percentage of should be within 98.0 101.0% of dried substance. The percentage of purity for both samples is within the range stated in the BP. The mass obtained from the titration of N-acetylcysteine solution with 0.1M sodium hydroxide with phenolphthalein as indicator for first titration is 0.3224g and second titration is 0.3440g. The percentage of purity obtained from the experiment for first sample is 107.43%. The percentage of purity from second sample is 114.67%. According to British Pharmacopoeia (BP), the percentage of should be within 98.0 101.0% of dried substance. The percentage of purity for both samples is out of the range stated in the BP. Phenol red and phenolphthalein are acid-base indicators. The un-dissociated form of the indicator is a different colour than the iogenic form of the indicator. An Indicator does not change colour from pure acid to pure alkaline at specific hydrogen ion concentration, but rather, colour change occurs over a range of hydrogen ion concentrations. This range is termed the colour change interval. It is expressed as a pH range. The pH range for phenol red is 6.8- 8.4 and phenolphthalein is 8.0- 10.0. The selection of indicator will depend on the actual expected pH at the equivalence point which selects an indicator with a pKa right in the middle of the pH change at the equivalence point. N-acetylcysteine solution has pKa 4.0 and 9.5, and a weak acid indicator has to be used to determine the end point of the titration. Phenol red produce a good result compared to the phenolphthalein as indicator when titrate N-acetylcysteine solution with 0.1M sodium hydroxide. d) Zinc: Not more than 10ppm Zinc (Zn): By performing the atomic absorbance technique, we have determined that the N-acetylcysteine sample contained a Zinc concentration of 2.4017ppm. This sample complied with the requirement from the British Pharmacopoeia (BP) monograph standards by not having a Zinc concentration of greater than 10ppm. Atomic absorbance technique can only detect specifically one heavy metal at a time. So, it is very time consuming to detect a wide spectrum of heavy metal impurities within our sample. Plus, the N-acetylcysteine monograph only indicates the need to monitor the level of Zinc present within the sample by atomic absorbance spectrometry. Therefore, to detect other heavy metals we would prefer to use the more generic Limit Test C for Heavy Metals as specified in the British Pharmacopoeia (2008), Volume IV, and Appendix VII. e) Loss on drying: Not more than 1.0% w/w:- According to British Pharmacopoeia (BP), it states that there should be no more than 1.0% in mass. This sample is complied with the BP monograph standards with a loss of only 0.66% in mass. f) Related substances:- HPLC is used in pharmaceutical analysis to quantitative determinations of drugs in formulations. These analyses do not require long time to optimising mobile phase and selecting columns and detectors. Some formulations contain more than one active ingredient and may present more of an analytical challenge since the different ingredients may have quite different chemical properties and elute at very different times from HPLC column. 5. Conclusions: Quality control is an essential operation of the pharmaceutical industry. Drugs must be marketed as safe and therapeutically active formulations whose performance is consistent and predictable. A bundle of sophisticated analytical methods are being developed for the drugs evaluation in pharmaceutical industry. Requirements governing the quality control of pharmaceuticals in accordance with the British Pharmacopoeia (BP) or European Pharmacopoeia. Titration is a procedure used in chemistry in order to determine the molarity of an acid or a base. A chemical reaction is set up between a known volume of

The Scarlet Letter and the Egg-carton Essay -- Scarlet Letter essays

The Scarlet Letter and the Egg-carton An analogy between two subjects can often lead to a better understanding of one or more of the topics. This point can be displayed by a comparison between the classic novel by Nathaniel Hawthorne, The Scarlet Letter, and a normal egg-carton. An analogy can be made between the concealment of secrets in the novel and the concealment of the eggs by a closed egg-container. Also, a correlation can be made between the revealing of secrets by the characters in The Scarlet Letter and the revealing of the many eggs by an open egg-carton. Lastly, the characters in the novel protect others as an egg carton protects its eggs. Both an egg-carton and The Scarlet Letter provide examples of concealing, revealing, and protecting. As a closed egg carton hides its contents from view, so the characters in Nathaniel Hawthorne's novel hide their shame and secrets. Certain characters in The Scarlet Letter take great lengths to conceal their secret shame. Hester Prynne, the adulterous lover to Reverend Dimmesdale, lied in order to conceal the true meaning of her Scarlet Letter from her daughter, Pearl. Hester tells Pearl, "... as for the scarlet letter, I wear it for the sake of its gold-thread" (Hawthorne 166). Hester's guilt ridden lover, Reverend Dimmesdale, concealed his shame as well. As he himself phrased it, "Cowardice which invariably drew him back [from revealing he was Pearls father], with her tremulous gripe, just when the other impulse [remorse] had hurried him to the verge of a disclosure" (Hawthorne 136). In Dimmesdale's case, it was his fear of shame that kept him from acknowledging his part in Pearl's creation. Besides concealing their shame, the charact... ... did finally figure that the Minister Dimmesdale was Hester's lover, Hester decided to warn Dimmesdale. She warned the Minister because as she believed, "the sacrifice of the clergyman's good name, and death itself, would have been preferable to the alternative [Dimmesdale's torment] which she had taken upon herself to choose." (Hawthorne 177). The novel The Scarlet Letter by Nathaniel Hawthorne can be compared in several ways to an egg-carton. A closed egg-carton can conceal its contents as characters have concealed their secrets. An open egg-container can reveal its eggs as the characters in the novel have revealed secrets. An egg-carton can protect its eggs and Hester Prynne can protect those who were important to her. The novel The Scarlet Letter, when analyzed in depth, can be found to be an even greater piece of American literature.

A Comparison of The Grapes of Wrath and Anthem Essay -- comparison com

Comparing The Grapes of Wrath and Anthem      Ã‚  Ã‚   Two great intellectuals of the early twentieth century wrote works of fiction that have become classics; they espoused polar-opposite views, however, of how society best functions. Their battle between communalism, as pictured in John Steinbeck's The Grapes of Wrath, and individualism, as portrayed in Ayn Rand's Anthem, was played out in their novels, and still continues to this day. Based on Ayn Rand's book Anthem, Rand would definitely believe that there is a greater danger involved in communalism than in individualism. The book offers a vision of a distant retrograde future in which the candle is the newest invention; individualism has been completely suppressed; and one of the most commonly used words today, "I," is completely unheard of. The book celebrates the heroism of an individual - the main character, Equality 7-2521 - in his fight to promote individual achievement. Once banished for his individualistic beliefs, he and his girl, Liberty 5-3000, discover the wonders of human freedom and the word "I." With his newfound gift, Equality 7-2521 pledges to return to the civilization and destroy the oppression of the collective spirit, and liberate humanity into "a world in which each man will be free to exist for his own sake." It was mainly written as a response to the widening acceptance of philosophies of totalitarian governments, but also to the belief of sacrificing individual liberties for the public good, ever-present during the "Red Scare." In place of these ideas, Rand developed her theory of "Objectivism," which celebrates reason, capitalism, and individuality. Rand expresses these beliefs throughout the entirety of the book by showi... ... has to be both. Also, it is good to sacrifice a little bit for the greater good, but you can't sacrifice as much as you would in communalism or as little as in individualism. For example, the sacrificing of civil liberties during the now-present "War on Terrorism" is becoming too great of a sacrifice; also, in the case of Enron, they didn't sacrifice enough, and the result was devastating to many people. Ayn Rand and John Steinbeck, from the perspective of the very early twentieth century, have set forth in their novels opposing views that continue to be debated in the twenty-first century. Based on current events, it seems highly unlikely that the argument over Individualism and Collectivism will be resolved soon, if ever. Sources Rand, Ayn   Anthem New York: Signet 1961. Steinbeck, John. The Grapes of Wrath. New York: Penguin Books, 1978.

Communication In the Workplace Essay -- Effective Communication

In an interview with George Lakoff, a linguistics professor at the University of California, Berkeley, Ian A. Boal examines the social, political and economic implications of language and its relationship to the conduit metaphor. The interview, published in Boal's essay, Body, Brain and Communication, takes a closer look at the conduit metaphor in connection with computers and communication on the Internet and World Wide Web. More importantly, Boal-who is also a Berkeley professor-solicits Lakoff's views of computer technology and artificial intelligence; their effects on human values and the basic way people communicate and understand information in today's world. Essentially, the conduit metaphor enables thoughts and ideas to be communicated through connecting cables and wireless transmissions using language as objects and metaphors. An effective conduit metaphor causes the listener to receive and understand the meaning behind a message without having to engage in too much thought. Comprehension of an idea is achieved intuitively, instinctively or with feeling. The conduit metaphor is a basic parable belonging to a larger family of metaphors, many of which can be found on Lakoff's Conceptual Metaphors home page at Berkeley's Cognitive Science web site, http://cogsci.berkeley.edu/. The conduit metaphor, as described by its creator Michael Reddy, suggests that the mind can interpret ideas as objects that can be put into words, and thoughts are the organization or manipulation of those objects. Reddy says the objects that make up words or language reside in a storage container, or memory, where thoughts and ideas can be retrieved or recalled when needed. When ideas are converted into words, they can be communicated to someo... ...perform many of their job functions. Just imagine, however, if computers had the ability to not only assume a particular function, but also could think and reason in the same manner as you and I. Are human beings really ready for this type of innovation? The answer to this question may come sooner that we think. Works Cited Boal, Ian A. Body, Brain and Communication: An Interview with George Lakoff. Composing Cyberspace. Ed. Richard Holeton. Boston. McGraw Hill Publishing. 1998. (21-31). Ehrenreich, Barbara. Put Your Pants On, Demonboy. Composing Cyberspace. Ed. Richard Holeton. Boston. McGraw Hill Publishing. 1998. (80). Lakoff, George. Conceptual Metaphors. 22 Mar.1994. 23 Mar. 2000. http://cogsci.berkeley.edu/ Shirley, John. Wolves of the Plateau. Composing Cyberspace. Ed. Richard Holeton. Boston. McGraw Hill Publishing. 1998. (135-141).